Meis (Bryers), Myra Elinor – Aged 96 of Ocean City, NJ

first_imgMyra Elinor Meis (Bryers)In her 96th year, our mother Myra went peacefully up the golden stairs, joining beloved family and friends. She was born on January 21st, 1921 in Philadelphia to Irish immigrant parents, Anna and William Bryers. Myra graduated from John W. Hallahan Girls’ High School in 1938. In 1947, she met her flyboy, Bill, and they were married in 1949 for 67 years. She and our Dad always put family first and worked so hard to create a wonderful life together. Above all else, Myra’s love for her family was unmeasurable and unwavering. Myra and Bill were exceptionally proud of their 5 children, Myra (Birdie) and son-in-law Jerry Corcoran, Dr. William J. (Billy) and daughter-in-law Dr. Mary Lou Schneiders, Judith (Judy) and son-in-law Michael Ragan, James (Jimmy) and daughter-in-law Jacquelyn Quilter and Dr. Gerald (Jerry). Nanny was blessed with and loved by her grandchildren, Maura and husband Joe, Andrew, Kevin and wife Kristin, Alexandra, Marc, Courtney, Katie, Thomas, William and Theodore, as well as her great grandchildren, Elinor and William. Myra and Bill owned and operated the Tradewinds Motel in Ocean City, while vacationing with family and friends in Florida during the winter months. Our Mom was an amazing role model. She was welcoming to people from all walks of life and always quick to offer her generous heart. Her wisdom, strength and love were unparalleled and will forever live on in our hearts and minds. Never without her blue eyeshadow, our Mom was a maxxinista with a gold belt in shopping and tag-sailing. Knowing that she was moving on, we asked her if she had any words for us. Without missing a beat, her short response speaks volumes to her character and her values, “no I guess over the years, you’ve had all my words! All I really have to say is Thank You.”A Mass of Christian Burial will be offered Wednesday, December 7, 2016 at 11o’clock from St. Augustine’s R. C. Church of St. Damien Parish, 13 th Street at Wesley Avenue, Ocean City, NJ where friends may call from 9:30 until 10:45. Entombment will follow in Holy Cross Mausoleum, Mays Landing, NJ.Memorial contributions are suggested to Cystic Fibrosis Foundation. www.godfreyfuenralhome.comlast_img read more

Indiana health leaders believe state’s COVID-19 positivity rate has been understated

first_img Pinterest Indiana health leaders believe state’s COVID-19 positivity rate has been understated Google+ By Network Indiana – December 23, 2020 2 365 Twitter Twitter Pinterest WhatsApp CoronavirusIndianaLocalNews Google+ WhatsApp Facebook Facebook (Photo supplied/State Of Indiana) Indiana’s been understating its coronavirus positivity rate.The percentage of tests coming back positive peaked at 16.8% in April, and dropped as low as 3.5% in June — it’s 12.1% now, now. But state health commissioner Kris Box says all those numbers are two or three points too low. She says the department discovered a coding error several weeks ago in the software used for Indiana’s COVID dashboard. Box says the department has been working since then to confirm the mistake, and work with independent data scientists on a fix.Box says the figures will be corrected next Wednesday, when Indiana updates its color-coded risk scores for each of the state’s 92 counties. At the same time, the state will implement a change in the method it uses to calculate county-level positivity, one of the components of the risk score. Until now, the state has taken seven days of daily positivity rates, and averaged those percentages. That method means a one-day spike or lull can throw off the data for the whole week. The state will switch  to a straight average, dividing the number of cases in a week by the number of tests.Box predicts the effect of that change will be a mixed bag, with some county rates going up and others going down.The risk scores are used to determine how strict capacity limits should be for mass gatherings. Currently, 24 counties are rated at high risk. Ten others were just downgraded to “approaching high risk,” but won’t have their restrictions loosened until they maintain that improvement for a full week. Gatherings in those 34 counties are capped at 50 people.Box says while the percentages have been off, the state’s trend line will be the same as it was before, but at a higher level. She says the state’s other virus data, including the numbers of cases, tests, hospitalizations and deaths have been accurate. Previous articleBraun working to prevent PPP loans from being declared as taxable incomeNext article33-year-old struck, killed by vehicle on State Road 23 in South Bend identified Network Indianalast_img read more

Speech: Chief Secretary to the Treasury Liz Truss speech to the London School of Economics

first_imgCheck against delivery IntroductionAs an economics geek, and a committed free marketer, I’ve always admired the London School of Economics.Despite its left-wing reputation, it was the academic home of Hayek.But even more than that, it produced my husband, Hugh O’Leary.It means that whenever I want a late night discussion about supply side reform or econometrics, there’s always someone on hand.The permissive societyAnd why do I love this stuff?Because I care about freedom.I’ve never liked being told what to do. And I don’t like to see other people being told what to do.Britain is a country that is raucous and rowdy.We have a younger generation of self-starters growing up, who are desperate shape their own futures. Who reject hierarchy and understand the networked world and who want to take on the establishment – and win.That’s not just a healthy attitude to have in life. I believe it’s key to our economic future.I believe that our future lies in cultivating their maverick spirit.I want our economic model to be one where it’s not about the state deciding what you do, it’s about you deciding what you do.And from the grainbelt of our agricultural heartlands, to the brainbelt bursting out around our great universities…From the port cities to the inland empires.With greater freedom, all of these places have the capacity to do and be more.Truly free enterprise has huge economic benefits, driving down prices and creating growth and jobs.It breaks down monopolies, hierarchies and outdated practices.It destroys barriers, and erodes inequality.It’s good for business, and it’s good for our nation of Airbnb-ing, Deliveroo-eating, Uber-riding freedom fighters. As the LSE’s own Lionel Robbins said: “every day, thousands of people cast their votes for the hundreds of products and services on offer, and from the competition to win votes, better and better products and services arise.”We all benefit from the creativity and innovation of a free market.New gadgets may begin in the hands of the wealthy few.But they most often end up improving all our lives.From the bricklayer to the banker, we all use the same smartphones.There’s no more important time to be thinking about this.Britain has a unique opportunity to re-establish itself as the land of the free.After surviving the financial crisis and launching the Brexit process. We can put public finances on an even keel, and drive progress through economic liberalisation.Our Industrial Strategy will guide us towards achieving that. It sets out how we are building a Britain fit for the future – how we will strengthen our skills, bolster our industries, and build the infrastructure we need to boost productivity and the earning power of everyone throughout the UK.We already have a strong base, with a record number of start-ups, and record levels of employment.But if we get the next phase of our development right, if we liberate every part of our economy, we can truly turbocharge growth.Freedom to workI believe that liberating the economy has to start with the individual, and helping more people get into jobs.Work isn’t just about feeding your family.It’s about your sense of self and independence.What we’ve done as a government, is help more people gain that independence.Since we came to power, we have reformed employment law, making it easier for companies to take on staff.We’ve widened access to professions, making it easier to train as a teacher or lawyer.We’ve taken huge strides to even the playing field for women in top professions.We’ve also built on a history of supply side reform in the labour market.In the 1980s, Mrs Thatcher curbed excessive union power which created barriers to entry and meant cronyism was the key to climbing the ladder. More recently, it was the welfare state that was holding people back, and our changes released millions who were trapped in poverty into well-paid work.[POLITICAL CONTENT REMOVED]But the results prove them wrong – we now have record employment and the lowest unemployment rate since 1975 which has reduced inequality.Meanwhile, our European neighbours with labour markets much more restrictive than ours are struggling.France’s unemployment rate is double ours, while in Spain and Italy it’s even worse.But there are still barriers stopping people getting into work in this country. Often these are barriers as thin as a sheet of paper.Because Britain has a higher proportion of licensed workers than France, Italy or Belgium.When well-designed, professional qualifications can ensure the public are protected from harm.But for those without the funds or family connections to break in from outside, finding work can be frustrating.In the 1980s, it was unions that were holding people back from getting jobs – now it’s over-regulated occupations.And for consumers, it can mean less choice, and higher prices.So if we can reduce these barriers, everyone will benefit.I want to liberalise unfair regulation to make it easier for people to follow their dreams and start new careers.I want to challenge unfair rules and fees, and make sure that barriers are not being put up to important industries in the UK economy, I will explore taking forward a cross-government review of occupational licensing.Freedom to liveFor that individual following their dreams, there needs to be affordable housing wherever they want to live. If I see an opportunity I want to get a piece of the action.I want to surf the zeitgeist to where it’s all happening.When I moved to London from Leeds as a graduate in the 1990s, I came because of the opportunities on offer here.Back then, I could afford to find somewhere to live.And now, having benefited from that opportunity, it would be wrong of me to deny it to others.This government has delivered more affordable homes.[POLITICAL CONTENT REMOVED]But too many people that have got themselves on the ladder have been allowed to pull it up behind them.Which means that young people these days can struggle to get flats near their jobs.According to the Resolution Foundation, the share of working age people moving for jobs has gone down by 25 per cent since 2001.And this is hitting people in the pocket – they estimate the average earner would have been £2,000 better off if they were able to get on their bikes.If we sorted this out, it could give a boost to individual workers, and to the economy.Evidence from America would suggest so.A recent study in America by Hsieh and Moretti showed that freeing up housing regulations in New York, San Jose and San Francisco to median levels could increase the US’s GDP by 3.7 per cent.But the most productive cities are being held back by restrictive regulations.It’s much the same story in the UK – restrictions on building are holding cities up.Our housebuilding rate peaked in the 1830s – long before we had cranes and diggers – simply because there were fewer planning restrictions.That’s why I’m heartened by groups like London Yimby, who want to open up planning.It’s the right and fair thing to do for people.And it would be one of the fastest ways of boosting our country’s productivity.In Japan, things are different.In the early 2000s, they relaxed their urban development rules, giving people the freedom to change their property as they see fit.And commercial developers are free to do as they please in designated zones.It all means that whereas house prices doubled and quadrupled in London and San Francisco – they were much flatter in Tokyo.It’s restrictions that are causing problems, so we need to liberate.We should densify our built environment, and look at making it easier for local neighbourhoods to raise the height of their houses.All this affects businesses too.They need access to the best talent, and the benefits that come with economies of scale.So I want to see us remove the barriers to prosperity in high growth areas.That’s why we’re piloting a manufacturing zone in the East Midlands, where some aspects of planning are pre-agreed – with a nod to the Japanese system – helping manufacturers get straight to work on building their factories.And I want to work with industry to see if more Development Corporations, like the one we used to build Canary Wharf, could be a success.[POLITICAL CONTENT REMOVED]Freedom to do businessFor many people, following their dreams doesn’t just mean getting the job that they want…It means starting a business of their own.And those people should have the freedom to fight for their place in the market.I see it as my role as Chief Secretary to the Treasury to be on the side of the insurgents – I see myself as the disruptor in chief!Because British people love change.From the adoption of the latest gadgets – the microwave meal, to the smartphone to being one of the most socially advanced, modern countries in the world…This ancient rock of Northern Europe has always been at the forefront of progress.I saw a recent IPSOS Mori poll which showed that, of 23 of the world’s most advanced economies, British people were the least likely to say that the world is changing too fast.We have some of the highest start-up rates, and fastest-adopting consumers in the world.We’ve embraced new apps like Citymapper and JustEat because they have given us extra freedom, and because they have given extra work and income to people often on the fringes of society.Most of us welcome all this change, but some have a stake in the status quo.The blob of vested interests campaign for a thicket of regulation to surround incumbents and protect them from competition.The government should take these vested interests on, and free the disruptors to bring life to the market and empower those on the margins.Sometimes, traditional businesses face regulatory barriers that disruptors don’t.For example, I’ve heard from a guesthouse in my constituency that had to gain two licenses to let his guests listen to the radio. Airbnbers don’t have to worry about the same restrictions.And commercial TV is price capped on advertising, while their competitors on the internet – including Google – are not.But the answer isn’t to increase regulation, and keep everyone back.I believe that the answer is to look at whether the regulations that we have are fit for purpose, to reduce barriers for everyone, so that competition is a fair fight.Because we should reward those with the brightest ideas, rather than those with the biggest legal departments.I’ve already mentioned what we could do with housing and planning in this country.But could we reduce energy bills by simplifying regulation and enhancing competition?Or encourage growth by cutting fees and regulations for businesses, rather than offering further subsidies that benefit incumbent firms?I want us to do everything we can to make things fairer, simpler, and easier for businesses to compete.Many of the rules that we have in place are important in guaranteeing public safety.But it’s hard to shake the feeling that sometimes they just get in the way of consumer’s choices and lifestyles.And government’s role should not be to tell us what our tastes should be.Too often we’re hearing about not drinking too much……eating too many doughnuts……or enjoying the warm glow of our wood-burning Goves…I mean stoves.I can see their point: there’s enough hot air and smoke at the Environment Department already.A guy in my constituency, who brought in £10,000 a year to Mundford Football Club by setting up advertising hoardings around the ground, had to take them down, after one person complained to the council.If Frances McDormand can put up three billboards outside Ebbing, Missouri, why can’t we do the same in King’s Lynn, Norfolk?I’ve heard that the EU are debating a copyright law that could ban memes from the internet…In my own words. That. Is. A. Disgrace.Or take burgers. I keep being told by excellent burger producers, whether it’s the Burger Shop in Hay-On-Wye or Bleecker Street in London, that there are strict restrictions against selling medium rare.Why can’t I as a consumer decide, as I would be in most parts of the USA, or France?Regulations against my tastes in burgers may see a little trivial, but they are symptomatic of a broader malaise.Unnecessary red tape restricts business and consumer freedom, so I believe we should cut it wherever we can.Freedom to tradeFinally, we should extend our liberal economic outlook to the world.Because if your business grows so big you want to expand overseas, you should have the freedom to do that.Brexit comes with a host of opportunities, and surely one is that Britain is well placed to make the case for open and liberal trade.Doing so will bring the same benefits as for economic liberalisation at home: broadening choice for consumers, and increasing competitive pressures on businesses.Trade as a proportion of GDP – a traditional measure of openness – is 78 per cent of GDP in South Korea, compared to 58 per cent of GDP in the UK.And every extra percentage point of openness increases productivity by 1.23 per cent, so if we matched South Korea in the long run, this would give a massive boost to our GDP.The sleek stateFor people and businesses to have the best opportunities, government has an invaluable role in educating our children, keeping us healthy, investing in world-class infrastructure and keeping markets fair and open.But we should also be constantly vigilant that the state does not balloon out of control.Because the more government spends, the higher taxes have to be.And that means less money for businesses to spend on their own priorities, like the farm in Lincolnshire that needs a new machine to automate potato picking.[POLITICAL CONTENT REMOVED]And higher tax means less money for me to decide when to go on holiday or buy a new car.The Spending Review taking place next year gives us an opportunity to address this.It gives us a chance to get debt down, modernise Government and keep control of the size of the state.Responsibility for the public financesI have to confess it can be lonely at the Treasury.Poring over the spreadsheets, freezing with the heating off in winter or sweltering with zero aircon in the summer.The only excitement is helping yourself to the Chancellor’s secret KitKat stash.It can sometimes feel like there’s always a party going on that you’re not invited to – particularly when the Foreign Office is next door.While everyone around is spending money or at the very least talking about it, we are the preachers of prudence.Over the past 8 years, we have cut government waste whilst focussing on quality and value for money in our public services. Overall we’ve reduced government spending from a whopping 45 per cent of GDP to 39 per cent, meaning we could cut tax on the lowest paid whilst maintaining world class public services.We have cut the deficit by three-quarters, to just over 1.9 per cent now.We are now on course for debt to be falling as a share of the economy by this year.It’s precisely because of this prudence, that we’ve been able to boost funding for the NHS.The settlement, which was done on an extraordinary basis, outside the Spending Review, because we recognised the real pressures in this service, is only possible due to the government’s economic credibility.It’s only because we’ve kept purse strings that we have been able to do this.And that’s why we need to continue on our path.Despite everything we’ve done, we’ve still got the highest debt for fifty years at 85 per cent of GDP.And we need to turn this around.Because high debt can dissuade investors. And the OBR have warned that if the UK is hit by a shock this could send debt over 110 per cent of GDP.[POLITICAL CONTENT REMOVED]Setting up the OBR and developing our fiscal rules have helped us counter this tendency, and put Britain on a path to lower debt.Other countries have followed a similar path.Switzerland and Chile have shown that flexible yet robust fiscal rules can be designed which balance budgets over the business cycle.These rules are self-discipline mechanisms, which help ensure that governments do not get carried away.[POLITICAL CONTENT REMOVED]The big state is not inevitableSome people argue that, as a country’s population becomes older, the state must take an increasing share of the economy.But there are many aging countries with advanced economies that do not have high tax and spend.Instead, they deliver really high quality services, with less waste and at better value for money.Japan has an old population with a median age of 47, compared to Britain’s 40.But their spending as a share of GDP is slightly lower than the UK’s.Japanese colleagues told me that they recently raised VAT to 8 per cent – and that was causing consternation!South Korea, meanwhile, has a comparable median age to Britain, but a very small state.Their government expenditure is only 32 per cent of GDP.All these countries are facing similar problems, but are finding solutions.We shouldn’t necessarily seek to emulate everything these countries do: Japan has debt levels of 200 per cent GDP, while South Korea’s economy is driven by a small number of conglomerates.But the point remains: an aging country does not ipso facto mean a country with high tax and spend.Even countries that we sometimes think of as having big states are realising that governments should seek to do less, better.Canada, after the misconceived expansionist years in the 1960s, when they raised taxes and nationalised businesses…rescued their economy in the 90s by cutting spending and balancing the budget.Sweden had a similar story. In the two decades since their banking crisis in the early 90s, they kept a tight hand on their budget and overhauled their sprawling welfare state.As a result, their economy has been transformed in the two decades since their banking crisis.All across the world, countries are addressing their problems not simply by raising tax and spend, but by reshaping and reinventing themselves.It’s not macho to demand more moneyThat means creating a sleek, effective, sharp and focused public sector.Yes, we all want well-funded, high-quality public services.But government has a responsibility to live within means, ruthlessly pursue efficiencies, eliminate waste, and constantly re-examine the scope of government in a world of constant technological change.As a Government we are spending £800bn, the equivalent of £29,000 per household.We spend more than Germany or Japan on schools per student and our spending on health, currently at the Western European average, will match France’s by 2024.We spend a higher proportion on welfare and pensions than most of our European neighbours, too.But often government budgets are simply rolled over from the year before, rather than being rigorously reappraised based on their merits.We need to look at budgets with fresh eyes, and think more as a start-up would.Those familiar with the 1984 film Gremlins – will recall how the cute Gizmo, when fed after midnight, turned into a slime-soaked baddie Stripe.In much the same way, there’s a tendency for governments and bureaucracy to multiply and exert further control. And before you know it gremlins are everywhere.There is a temptation to feed these creatures after midnight.But more widely we have to recognise that it’s not macho just to demand more money. It’s much tougher to demand better value and challenge the blob of vested interests within your department.Some of my colleagues are not being clear about the tax implications of their proposed higher spending.That’s why, in next year’s Spending Review, I want to take a zero-based, zero-tolerance approach to wasteful spend.We need to take a look at ourselves and think “what is the best way to use the money entrusted to us?”We have to make every pound pull its weight. We have to make every pound pull its weight.The digital stateAs well as re-examining what the state does, we should also look at how it does what it does.David Cameron spoke about the post-bureaucratic age and an information revolution but we’re still wading through paper.The box that I take home every night groans and creaks with documents.It feels less like the post-bureaucratic age and more like the most-bureaucratic.So it’s my ambition that we transition to a digital, no-paper state within a generation.And according to a report from Reform and Deloitte, if we fully rolled out artificial intelligence in Government – we could save £17bn.Fiscal discipline and economic liberalisation are two parts of the same story: the desire to give people power over their own money and their own lives.Many people voted for Brexit because they wanted to take control of their own lives. And the public will find it unforgivable and a betrayal of Brexit if just as we embark on a bright future outside the EU – we impose higher and higher taxes on them taking away the control they have over their own money.This is a complete contradiction of the Brexit vote.If that’s not enough to convince anyone, then a look at the alternatives should.[POLITICAL CONTENT REMOVED]Living in a stagnating country that was utterly boring, with the government controlling more of our lives.Or there’s the option pursued by some other Western nations – carry out some regulatory and tax reforms – and see an economic boost.But also let fiscal responsibility slide and allow the deficit to balloon.We’ve been there before. It leads to boom and bust.[POLITICAL CONTENT REMOVED]More spending, more state control, and runaway debt. This would lead straight to penury.As Paul Ryan said, it would lead to a world where everything is free – except us.Economies and societies are stronger when individuals, families and businesses have the freedom to decide for themselvesBy giving them all more power – we have the ability give our country the huge economic boost it needs.last_img read more

Roberts educates local children for Breakfast Week

first_imgRoberts Bakery, the Cheshire-based firm, teamed up with Kerrygold to educate local schools for Breakfast Week.Organised to support the Shake Up Your Wake Up initiative, part of Breakfast Week, Roberts and Kerrygold spoke to 500 Staffordshire youngsters at Seabridge Primary School in Newcastle-under-Lyme about how to start the day right.The event aimed to teach children about how to put a tasty yet healthy breakfast together using good, basic ingredients. The pupils enjoyed buttered toast with a variety of healthy toppings including honey and banana, as well as fresh fruit, yoghurt and juice.Studies from the Agriculture & Horticulture Development Board (AHDB) Cereals and Oilseeds have shown that eating breakfast can give you more energy, improve concentration and enhance mood. Dietary fibre found in complex carbohydrate foods, such as bread, also means that food is digested more slowly so children stay fuller for longer.Alison Palmer, marketing manager for Roberts Bakery, said: “By making it fun and giving youngsters the chance to be creative, we are helping to educate them and their families on the role of bread in a healthy diet and as a way of keeping energy levels up and achieving goals in school.”last_img read more

Gene silencing may cause limitations of induced pluripotent stem cells

first_imgScientists may be one step closer to being able to generate any type of cells and tissues from a patient’s own cells, according to the results of a new study by Harvard stem cell researchers at Massachusetts General Hospital (MGH).Konrad Hochedlinger, PhD, an associate professor in Harvard’s inter-school department of stem cell and regenerative biology (SCRB), and colleagues describe finding that an important cluster of genes is inactivated in induced pluripotent stem cells (iPS) that do not have the full development potential of embryonic stem cells.Generated from adult cells, iPS have many characteristics of embryonic stem cells but also have had significant limitations.“We found that a segment of chromosome 12 containing genes important for fetal development was abnormally shut off in most iPSCs,” says Hochedlinger, a Harvard Stem Cell Institute Principal Faculty member and member of the MGH Center for Regenerative Medicine. “These findings (in mice) indicate we need to keep improving the way we produce iPSCs and suggest the need for new reprogramming strategies.” The study has received advance on-line publication from Nature, and will appear at a later date in the journal’s print edition.Although iPSCs appear quite similar to embryonic stem cells and give rise to many different types of cells, they have important limitations.Several molecular differences have been observed, particularly in the epigenetic processes that control which genes are expressed, and procedures that are able to generate live animals from the embryonic stem cells of mice are much less successful with iPSCs.Previous studies have compared iPSCs generated with the help of viruses, which can alter cellular DNA, to embryonic stem cells from unrelated animals. To reduce the chance that the different sources of the cells were responsible for observed molecular differences, the MGH/HSCI research team prepared two genetically matched cell lines. After generating mice from embryonic stem cells, they used a technique that does not use viruses to prepare lines of iPSCs from several types of cells taken from those animals. They then compared the iPSCs with the original, genetically identical embryonic stem cells.The most stringent assay of cells’ developmental potential showed that two tested lines of embryonic stem cells were able to generate live mice as successfully as in previous studies, but no animals could be generated from genetically matched iPSCs. Closely comparing RNA transcription profiles of several matched cell lines revealed significantly reduced transcription of two genes in the iPSCs. Both genes are part of a gene cluster on chromosome 12 that normally is maternally imprinted – meaning that only the gene copies inherited from the mother are expressed.Examination of more than 60 iPSCs lines developed from several types of cells revealed that this gene cluster was silenced in the vast majority of cell lines. While the gene-silenced iPSCs were able to generate many types of mouse tissues, their overall developmental potential was limited. In an assay that produces chimeric animals that incorporate cells from two different stem cells, mice produced from gene-silenced cells had very few tissues that originated from the iPSCs. However, in a few iPSC lines the gene cluster was normally activated, and in the most rigorous developmental assay, those iPSCs were as successful in producing live animals as embryonic stem cells have been. The authors believe this is the first report of animals being produced entirely from adult-derived iPSCs.“The activation status of this imprinted cluster allowed us to prospectively identify iPSCs that have the full developmental potential of embryonic stem cells,” says Matthias Stadtfeld, PhD, of HSCI and MGH, a co-lead author of the report.” Identifying pluripotent cells of the highest quality is crucial to the development of therapeutic applications, so we can ensure that any transplanted cells function as well as normal cells. It’s going to be important to see whether iPSCs derived from human patients have similar differences in gene expression and if they can be as good as embryonic stem cells – which continue to be the gold standard – in giving rise to the 220 functional cell types in the human body.”Hochedlinger adds, “Previous studies in mice have shown that embryonic stem cells derived from nuclear transfer – the technique used to clone animals – are indistinguishable from stem cells derived from fertilized embryos Nuclear transfer is another way of reprogramming adult cells into embryonic-like cells, and comparing that approach with iPSC generation may yield important insights into ways of producing the safest and highest quality pluripotent cells for use in patients.”Efie Apostolou, PhD, of the MGH-CRM and HSCI is also a co-lead author of the Nature report.Additional co-authors are Patricia Follett, MGH-CRM and HSCI; Toshi Shioda, MD, PhD, MGH Cancer Center; Hidenori Akutsu, MD, National Institute for Child Health and Development; Sridaran Natesan, PhD, Sanofi-Aventis and Atsushi Fukuda and Tomohiro Kono, PhD, Tokyo University of Agriculture.Hochedlinger is a Howard Hughes Medical Institute Early Career Scientist and received a Director’s Innovator Award from the National Institute of Health.Additional support for the study includes grants from the Schering Foundation, the Jane Coffin Childs Memorial Fund and Sanofi Aventis.last_img read more

Rollout of Science and Engineering Complex

first_imgHarvard University took the first formal step toward Boston’s approval of its new Science and Engineering Center in Allston yesterday by filing its Institutional Master Plan Notification Form (IMPNF) with the Boston Redevelopment Authority (BRA). This submission kicks off a formal regulatory review of the project, which includes a 30-day public comment period.The complex, which will house the John A. Paulson School of Engineering and Applied Sciences (SEAS), will be among the most cutting-edge teaching and research facilities in the country, officials said, and will play an integral role in the evolution of Harvard’s campus in the decades to come.“The Science and Engineering Complex filing is a significant milestone for the University,” said Katie Lapp, executive vice president of Harvard. “This marks another exciting step forward in enhancing Harvard’s campus and activating Barry’s Corner in Allston.”The 497,000-square-foot project, fronting on Western Avenue, will include teaching and classroom space, research areas, retail space, a spacious atrium and cafeteria, and landscaped open space.“The expansion to Allston will not only provide SEAS with much-needed space, but new kinds of space for teaching, active learning, and cutting-edge research,” said Dean Francis J. Doyle III of the Harvard Paulson School. “In addition to state-of-the-art facilities, we look forward to the prospect of creative collisions that our faculty and students will have with colleagues from the Business School and eventually other Harvard units that will be part of the University’s Allston campus. The building will be a boon for SEAS and for the broader Harvard College community.”Harvard has partnered with Behnisch Architekten, a renowned architecture firm known for designing sustainable, innovative research buildings.“The design of the Science and Engineering Complex project pulls together a number of threads of contemporary life certain to influence coming generations: the engineering enterprise as a decisive influence in the discovery and resolution of some of the world’s most intractable problems; cross-disciplinary efforts as critical to major research initiatives; and genuine leadership in the area of sustainable design and urban development,” said Matt Noblett, partner at Behnisch Architekten.The Science and Engineering Complex is moving forward as part of a series of carefully sequenced development projects intended to activate Barry’s Corner with a blend of academic, residential, and retail buildings. Over the course of the past six months, Continuum, a mixed-use retail and housing development, opened in Barry’s Corner, and the former Charlesview apartments were demolished. The Harvard Ed Portal and the ceramics studio are both open and thriving. The i-lab and Launch Lab are attracting students and startups, and the Business School is moving forward on plans for Klarman Hall.Harvard continues to engage in planning related to the Gateway building on Western Avenue, which will eventually house a mix of academic and administrative offices. The University is currently exploring both the academic programming for and the specific timing of the construction of the building.Simultaneously, the environmental remediation of Beacon Park Yard North by CSX continues. This work is a condition of the eventual transfer of the property to Harvard and marks a key step in making the land available for the planning of the University’s future Enterprise Research Campus.Collectively, this sequence emerged as a revised strategy in 2011, necessitated by the economic realities in the post-recession economy. Projects anticipated over the next decade are outlined in Harvard’s Institutional Master Plan (IMP), which was given the community’s blessing and officially approved by the BRA in 2013.,As the Science and Engineering Complex proceeds through regulatory review, a robust community process will continue.“Harvard has a valued and longtime partnership with the Allston neighborhood and the city of Boston. The implementation of the Institutional Master Plan is unfolding, and has been strengthened by community input and support,” said Kevin Casey, associate vice president of public affairs and communications at Harvard. “We’ve been pleased with how the public process has evolved in the pre-filing meetings throughout the fall and look forward to continued conversations in the next phases.”“We’re pleased to see Harvard University move forward with plans for the Science and Engineering Complex in Allston, as this is an important step in the continued revitalization of the area around Barry’s Corner,” said Boston Mayor Martin J. Walsh. “Harvard has the opportunity to build on the momentum of other successful projects in the neighborhood, and we’re eager to continue facilitating a dialogue between the University and members of the community during the review process.”The University hopes to commence construction on the Science and Engineering Complex next summer, with an anticipated building opening in 2020. A total of 800 construction jobs are expected over the course of the project.last_img read more

SMC hall director Shea receives award

first_imgResponsible for supervising 10 resident advisors (RAs) and about 264 residents, McCandless Hall and Opus Hall director Kady Shea received the Advisor of the Year award for her work with the College Residence Hall Association (RHA). Shea has not only managed to keep order in the residence halls, but has helped make some vast improvements to the quality of life on Saint Mary’s campus.“[I really enjoy] getting to interact with students on a regular basis, and getting to know them personally, what’s going on in their lives and just being able to help them as best I can with whatever is going on,” Shea said.The award was presented at the Indiana Residence Hall Organization Conference on Feb. 6.Shea and LeMans Hall director Leslie Robinson co-advise RHA at the College.Shea was nominated by the members of RHA and was chosen by the directors of the Indiana Residence Hall Organization (IRHO).“The advisor of the year was pretty cool just because advising RHA is part of my job but its just one small piece of my job,” Shea said. “They nominated me for this award  and the directorship of IRHO recognized my accomplishment. That was pretty cool to receive that.”Shea began working at the College in August 2008. Since that time she has not only acted as a co-advisor for RHA, but as advisor for McCandless Hall Council as well. Additionally, she has worked to help improve RA training as well as the room selection process.Shea is also responsible for keeping the Residence Life Web site up to date.“It’s a challenge, but I also find it very entertaining,” Shea said. “I try to have a positive look at it. Working with Residence Life and being a hall director, you come into work every day not knowing what to expect. It’s not the type of thing where you log onto a computer and start entering numbers all day.”Shea decided to become a hall director during her undergraduate studies at Simmons College in Boston.  Shea said she originally wanted to be a teacher.“I always knew that I wanted to help people in some capacity,” she said. “I had a first-year experience class where I had a college administrator who facilitated the class and she actually worked in Residence Life and kind of opened my eyes to Residence Life. That’s when I discovered that you can make a career out of this and you can do everything you love, work with students and get paid for it.”Shea said she enjoyed working as a hall director at Saint Mary’s. She has had a positive experience with the RAs as well as the other residents in her halls.“I really enjoy working with first year students just because transitioning into college is not always easy and being able to help them with that transition is pretty awesome, and being able to see them grow through out the year,” Shea said.last_img read more

Leaner chicken

first_imgBy studying its body and genetic makeup, a University of Georgia geneticist wants to develop a chicken that converts its food into muscle mass, not fat, or simply one that is more healthful for consumers to eat.“What we know so far is animals that utilize feed efficiently also utilize calcium, energy and protein in their food much more efficiently,” said Sammy Aggrey, a quantitative and molecular geneticist with the UGA College of Agricultural and Environmental Sciences poultry science department. USDA funded researchTo conduct this research, Aggrey received a three-year $449,575 grant from U.S. Department of Agriculture Cooperative State Research, Education, and Extension Service.“Recently, because of technology, we are able to contain the whole chicken genome on a microchip,” he said. “We look at gene expression on this chip to determine which genes are turned on or off under different experimental conditions.” Currently, chicken accounts for 40 percent of the meat produced in the United States. Obese birds mean less meat yield, and smaller breast muscles equal less money at the market. Reducing fat and increasing breast muscle could improve production efficiency while meeting consumer demand for a leaner cut of meat, he said.Chicken diets are important, too“Feed constitutes 70 percent of production input,” Aggrey said. “If we could utilize less feed and yield the same or greater amount of protein we would increase efficiency. Animals that use feed more efficiently are less fat, so we will simultaneously correct two problems.” The same is true for humans. “People who use protein more efficiently are leaner than ones who use food inefficiently, and it is all due to genetics,” Aggrey said. Leaner chickens = leaner humansThe chicken genome has about 28,000 genes, a few thousand less than the 35,000 genes in the human genome. Aggrey and other scientists are mapping what traits the chicken genes represent. His goal is to isolate genes that regulate growth rate, fat deposits and muscle yield.“One important way to understand the human genome is to compare it with the genomes of different animals, such as the chicken,” he said. “The organization of the chicken genome is much closer to that of a human than a mouse or rat.” Unlocking this secret could mean a leaner piece of meat on the dinner table or a leaner person looking back in the mirror. “Our long-term goal is to breed efficient birds and, in the process, identify genes that are involved with obesity,” he said. “And that has both animal and human implications.” Aggrey is searching for additional grants to continue his research.last_img read more

Vermont Education chair Tom James stepping down

first_imgTom James, Chairman of the Vermont State Board of Education, announced today he will be stepping down from the Board. His final monthly meeting will be held September 15, 2009. James was appointed to the Board by Governor Douglas in February 2005 after filling two years of a vacant term. A retired IBM executive, James has served as a member of the Essex Planning Commission, the Essex Town School Board, the Essex Town Selectboard and the Essex Rotary. His State Board term was scheduled to end in 2011. However, State Board terms are six years in length, and James has served on the Board for over six years. He has served as State Board Chair since 2005.“I am both proud and humbled to have served on the Board for over six years, and I thank the Governor for appointing me twice to serve Vermonters,” said James. “Also, I am honored to have had my peers on the board elect me to serve as Chair for over four years. I am especially pleased to have participated in the initiation of the Transformation of Education in Vermont, which will ensure all students will be prepared when they graduate from high school to be successful in college, careers, and citizenship.”“I am deeply grateful for Tom’s dedicated service to the people of Vermont,” Governor Douglas said.  “Because education is the foundation of a strong and prosperous society, Tom’s efforts will continue to pay dividends for our state for many years to come.”  “Tom James has been an advocate for improving student learning and through his leadership has helped initiate a transformational movement that will provide Vermont’s schools with the tools needed to prepare our students for the 21st century,” said Commissioner Armando Vilaseca. “Tom has addressed the difficult issues facing our system with grace, respect and perseverance. He will be sorely missed both for his leadership but also for his commitment to our students.”It is expected that a new chair will be chosen at the September 15, 2009 meeting.last_img read more

Enel begins construction of South America’s largest wind farm in Brazil

first_img FacebookTwitterLinkedInEmailPrint分享ReNews Biz:Renewables developer Enel has started construction of a 716MW wind farm in Brazil, the biggest project of its kind in South America.Enel will invest over €700m in the Lagoa dos Ventos project in the north-east state of Piaui, which is expected to enter operation in 2021. Lagoa dos Ventos, comprising 230 turbines, is sited in the municipalities of Lagoa do Barro do Piaui, Queimada Nova and Dom Inocencio.As well as being the largest wind project under construction in South America Lagoa dos Ventos is also Enel’s biggest wind farm worldwide.Enel Green Power head Antonio Cammisecra said: “The start of construction of this record-breaking wind project in Brazil is a major milestone for our presence in the country, which continues to be one of the most prominent markets for Enel Green Power.”Out of the wind farm’s total installed capacity, 510MW was awarded to Enel in Brazil’s A-6 public tender in December 2017 and is supported by 20-year power supply contracts with a pool of distribution companies operating in the country’s regulated market. Output from the remaining 206MW will be sold to retail customers on the free market.More: Enel turns sod on 716MW Brazilian giant Enel begins construction of South America’s largest wind farm in Brazillast_img read more