Statins Reduce Stroke Cardiovascular Risk in Cancer Patients Following Radiation

first_img News | Mammography | August 14, 2019 Imago Systems Announces Collaboration With Mayo Clinic for Breast Imaging Image visualization company Imago Systems announced it has signed a know-how license with Mayo Clinic. The multi-year… read more Image courtesy of Imago Systems July 29, 2019 — Cancer patients taking cholesterol-lowering statin medication following radiation therapy of the chest, neck or head had significantly reduced risk of suffering a stroke, and possibly other cardiovascular complications, according to new research. The research appeared in Journal of the American Heart Association.This is the first large study to explore whether statins reduce cardiovascular complications in patients who have radiation therapy for chest, head or neck cancer.More than half of cancer patients are treated with radiation therapy, which uses high doses of radiation to kill cancer cells and shrink tumors. While radiation treatment has become more precise and long-term survival rates have improved, the radiation can affect nearby healthy cells and cause side effects many years later.Radiation therapy side effects include scarring or thickening of arteries, and over time that can lead to blockages that cause heart attack and stroke. In fact, the authors point out that cardiovascular disease is the leading cause of illness and death among cancer survivors.The newly published study looked at whether statin medication, which reduces the formation of plaques that block blood vessels, might lower the risk of cardiovascular and cerebrovascular disease after radiation therapy to the chest, neck or head. The researchers found that the use of statins was associated with a 32 percent reduction in stroke.There was also a strong trend toward reduction in overall cardiovascular events, such as heart attacks and stroke, and death due to those cardiovascular events. The authors said, however, that the 15 percent reduction they found was not statistically significant due to the high-risk population of patients in the study.“Statins decrease cholesterol levels and have anti-inflammatory properties. Multiple studies have revealed the beneficial effects of statin therapy on reducing the risks of vascular disease in a variety of populations,” said study author Negar Mousavi, M.D., M.H.Sc., at McGill University Health Center in Montreal, Canada. “Statins are protective in patients with heart disease, previous strokes and with high cholesterol levels.”For the study, the researchers studied data from 5,718 heart attack and stroke patients over age 65 (with a mean age of 75) at McGill University Health Centre in Montreal, Canada, who had undergone radiation therapy for chest, head or neck cancer from 2000 to 2011. The majority — 4,166 patients — were taking statins. Most of the people in the study had underlying cardiovascular disease.“Our study demonstrated that statin therapy could be favorable even with the competing risks of cancer and cancer-related mortality in patients who received radiation therapy,” said Mousavi who added, “No other agent is recommended with enough evidence to reduce the risk of vascular events among cancer patients receiving radiation to the head, neck or chest.”However, the authors point out that there is a need for prospective studies to explore the role of statins after radiation therapy in wider populations and to establish definitive guidelines on the management of radiation-induced vascular disease.Co-authors are Jacinthe Boulet, M.D.; Jessica Pena, M.D.; Edward A. Hulten, M.D.; Tomas G. Neilan, M.D.; Alice Dragomir, M.D.; Carolyn Freeman, M.D.; Christine Lambert, M.D.; Tarek Hijal, M.D.; Lyne Nadeau, M.D.; and James M. Brophy, M.D. Author disclosures are on the manuscript.For more information: www.ahajournals.org/journal/jaha Related Content Image courtesy of UTHealth McGovern Medical School Following radiation, the bone marrow shows nearly complete loss of blood cells in mice (left). Mice treated with the PTP-sigma inhibitor displayed rapid recovery of blood cells (purple, right). Credit: UCLA Broad Stem Cell Research Center/Nature Communications News | Radiation Therapy | August 15, 2019 First Patient Enrolled in World’s Largest Brain Cancer Clinical Trial Henry Ford Cancer Institute is first-in-the-world to enroll a glioblastoma patient in the GBM AGILE Trial (Adaptive… read more News | Neuro Imaging | August 16, 2019 ADHD Medication May Affect Brain Development in Children A drug used to treat attention-deficit/hyperactivity disorder (ADHD) appears to affect development of the brain’s… read more News | Brachytherapy Systems | August 14, 2019 Efficacy of Isoray’s Cesium Blu Showcased in Recent Studies August 14, 2019 — Isoray announced a trio of studies recently reported at scientific meetings and published in medica read more The MD Anderson Proton Therapy Center expansion is expected to be completed in 2023. Rendering courtesy of Stantec. Images of regions of interest (colored lines) in the white matter skeleton representation. Data from left and right anterior thalamic radiation (ATR) were averaged. Image courtesy of C. Bouziane et al.center_img News | Cardio-oncology | July 29, 2019 Statins Reduce Stroke, Cardiovascular Risk in Cancer Patients Following Radiation Cancer patients who took statin medication had a 32 percent reduction in stroke following radiation therapy to the chest, head or neck News | Proton Therapy | August 08, 2019 MD Anderson to Expand Proton Therapy Center The University of Texas MD Anderson Cancer Center unveiled plans to expand its Proton Therapy Center during a… read more Catalyst PT image courtesy of C-RAD News | Radiation Therapy | August 16, 2019 Drug Accelerates Blood System’s Recovery After Radiation, Chemotherapy A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem… read more News | Stroke | August 16, 2019 Mobile Stroke Unit Gets Patients Quicker Treatment Than Traditional Ambulance Every second counts for stroke patients, as studies show they can lose up to 27 million brain cells per minute…. read more Reference1. Boulet J., Peña J., Hulten E.A., et al. Statin Use and Risk of Vascular Events Among Cancer Patients After Radiotherapy to the Thorax, Head, and Neck. Journal of the American Heart Association, June 19, 2019. https://doi.org/10.1161/JAHA.117.005996 FacebookTwitterLinkedInPrint分享 News | Pediatric Imaging | August 14, 2019 Ultrasound Guidance Improves First-attempt Success in IV Access in Children August 14, 2019 – Children’s veins read more News | Patient Positioning Radiation Therapy | August 15, 2019 Mevion and C-RAD Release Integration for Improved Proton Therapy Treatment Quality Mevion Medical Systems and C-RAD announced the integration between the C-RAD Catalyst PT and the Mevion S250i proton… read more News | Artificial Intelligence | August 13, 2019 Artificial Intelligence Could Yield More Accurate Breast Cancer Diagnoses University of California Los Angeles (UCLA) researchers have developed an artificial intelligence (AI) system that… read more last_img

Leave a Reply

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>